What is Ketotifen? Research Information

Discovery:

Ketotifen fumarate is an antihistamine and mast cell stabilizer that was first discovered in the 1970s. The discovery of ketotifen as an antiallergic and anti-asthmatic drug resulted from extensive research into the mechanism of action of antihistamines. It is now used to treat various conditions, from chronic allergic diseases such as eczema and hay fever to preventing certain types of cancer.

Ketotifen is an agonist for both peripheral H1 receptors and mast cells. This means that when it binds to these receptors on cells in the body, it can reduce their activity of them. Decreasing their activity reduces inflammation and other symptoms associated with allergies and asthma.

Mechanism of action:

Ketotifen Fumarate is an antihistamine drug used to treat various allergic conditions. It works by blocking the action of histamine, a naturally-occurring chemical in the body. Histamine is released during an allergic reaction and causes sneezing and itchy eyes. By blocking its action, Ketotifen Fumarate helps reduce these symptoms. It can also help inhibit the release of other inflammatory substances in the body, which can lead to further aggravation of allergic reactions.

Clinical Applications of Ketotifen Fumarate

Clinical applications of Ketotifen are becoming increasingly popular due to its potential to treat many conditions.

1. Allergic Rhinitis:

Ketotifen fumarate is used in the treatment of symptoms of allergic rhinitis, such as sneezing, itching, runny nose, and nasal congestion. The drug works by blocking the action of histamine, a substance released during an allergic reaction, which causes these symptoms.

• Asthma:

 Ketotifen is also used to manage asthma symptoms, such as wheezing, coughing, and shortness of breath. The drug works by stabilizing mast cells, which are involved in the release of histamine and other mediators of inflammation, thereby reducing the severity of asthma symptoms.

• Ocular Allergic Diseases:

 Ketotifen fumarate is commonly used to treat ocular symptoms associated with allergic conditions, such as itching, redness, and swelling of the eyes. The drug is often used in the form of eye drops, which can be applied directly to the affected area to relieve symptoms. Additionally, the drug’s anti-inflammatory properties can help reduce overall eye inflammation, leading to more severe ocular conditions.

Disclaimer

The information provided about Ketotifen in this section is only for research advancement and disbursement of knowledge. The material collected in this article is meant for informational purposes about Ketotifen Fumarate. It is not to be considered instructional in any way. Moreover, we have further empathized with this by making sure no dosage information of Ketotifen or recommendations about its way of consumption is mentioned. The information available in this article is a collection from different recognized studies and researches conducted by known experts and researchers in controlled medical facilities and institutions. Furthermore, the information provided in the article is not to encourage the reader to start its consumption or as an advertisement of the product. Administering any supplement or medication not FDA approved may be harmful and may cause serious illness.  Peptide Pros insist that none of their products be ingested under any circumstances.

References:

1. https://pubchem.ncbi.nlm.nih.gov/compound/Ketotifen-fumarate
2. Ketotifen-fumarat|Wikipedia|https://en.wikipedia.org/wiki/Ketotifen
3. Shu-Zhen, W., Yao, Y., Zhang, X. J., Duan, X., Liang-Rong, G., Jia, Y., … & Yong-Sheng, T. (2020). Combination treatment of allergic rhinitis using ketotifen fumarate and budesonide administered as nasal sprays. International Journal of Clinical Pharmacology and Therapeutics, 58(4), 195.
4. Ketotifen-fumarat|Sciencedirect|https://www.sciencedirect.com/topics/medicine-and-dentistry/ketotifen
5. Kidd, M., McKenzie, S. H., Steven, I., Cooper, C., & Lanz, R. (2003). Efficacy and safety of ketotifen eye drops in the treatment of seasonal allergic conjunctivitis. British journal of ophthalmology, 87(10), 1206-1211.

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