The purpose of this article is not to promote the recreational use of peptides, rather to debunk with facts some misconceived notions surrounding them. Also, to raise awareness of the mainstream media’s desire to sell newspapers, gain website traffic or viewership by using racy headlines and inflammatory articles, over the need to unbiasedly educate the general populace.
- Peptides Are Dangerous And Possibly Deadly – There is NO scientific or even ancillary evidence that supports this assertion. Unfortunately, news organizations get higher readership from headlines such as “Illegal Peptides May Be Fatal” than headlines like “Peptides May Help Millions of People”. In fact, there have been dozens of studies performed worldwide involving peptides and the worst known side effects when ingested by human participants were nausea, flushing, fever, increased libido and intense erections. That doesn’t sound deadly, unless you ‘re a girl on the receiving end of that side effect.
- A Woman Died in a Tanning Bed After Using MT-2 – This story is TRUE! Well, sort of… A woman did die in a tanning bed in England and yes authorities found she had Melanotan 2 in her system. However, the autopsy revealed that she died from heart failure linked to obesity. Also, that visit was her third visit in three days to the tanning bed (Sunbed death not linked to banned tanning jabs, n.d.). Melanotan 2 had NOTHING to do with her unfortunate demise; it was merely a coincidence. As a matter of fact, there was a recorded case (NCBI.nlm.nih.gov, n.d.) of a gentleman ingesting ten to twenty times the amount used in case studies and he did become slightly ill suffering nausea, vomiting and sympathomimetic excess and rhabdomyolysis. He went to the hospital and after an I.V. treatment was released 3 days later. According to the NCBI report, he also tested positive for opiates in his system so determining the cause of illness is impossible. Matter of fact, If you take ten-twenty times the dose of just about any over the counter drug, I imagine you’d experience similar illness or far worse. Take 40 Aspirin and see how your stomach lining fairs.
- Peptides Must Be Refrigerated At All Times – Most peptides are sold in a lyophilized state (that is simply a fancy word for freeze dried). In this state, they are presumed stable for up to approximately two years. Once the peptide is reconstituted (that’s a fancy word for mixed with water or a sterile solution of some sort) then the mixture begins to breakdown and it is recommended the peptide be refrigerated to help maintain its chemical structure. It’s said that once refrigerated the peptide will retain its integrity for up to 6 months. Therefor refrigeration is recommended once reconstituted but unnecessary prior.
- Mannitol Is Bad Or Is A Sign Of Low Quality Peptides – Not True and not sure how this rumor got started. Perhaps because when ingested in fairly large quantities it may cause diarrhea. Or because of its appearance it’s a popular substance to cut illegal drugs like cocaine. (Sorbitol vs. Mannitol, n.d.)Mannitol is a sugar substitute manufactured from fructose of corn starch and is used only to give the appearance of more substance in a vial. That’s it. I suppose if unscrupulous companies are making fake peptides and using mannitol as a substitute, then that is obviously bad. Most labs however, add it to peptides that are under 5 mg to give them a look of having a little more in the vial, WITHOUT negatively altering the actual amount of the peptide. Otherwise the vial looks so empty some researchers may be under the assumption they have been ripped off. Also, the addition of sucrose or mannitol has been known to help stabilize the peptide (NCBI.gov, n.d.)
- They’re Unapproved Or Banned Worldwide – Truth is many peptides have been approved and are currently available by prescription in many countries including Australia, Italy and Switzerland that have recognized their potential for a variety of applications. Other countries including the US have granted Phase III approval (ClinicalTrials.org, n.d.) for testing of many peptides and it would seem it’s only a matter of time before they gain approval.
- Peptides Are Not FDA Approved Therefore They Are Unsafe – Well, there is some truth to this, if they’re not FDA approved, then perhaps there is a safety concern involving the use of peptides. Furthermore, and just as important, in the US the ingestion of peptides are illegal due to the fact they are considered drugs and there is still a need for more tests to exam their long term effects on humans. Having said that, consider that most of the supplements in your local big name supplement store are not FDA approved but they’re protected under the Dietary Supplement Health and Education Act of 1994. Therefore millions of Americans ingest products that are NOT FDA approved and seem to gain benefits from such products, myself included. It’s estimated that the supplement business is a 35 billion dollar a year business. Seems as though a lot of people are ingesting things not approved by the FDA and not dropping dead.
- Nasal Sprays Are An Alternative Method Of Administering Melanotan 2 – When trying to get a drug approved, it is estimated that about 90% of all drugs don’t make it due to safety risks, side effects, lack of funding, miniscule potential for profitability, etc. Peptides in general are considered to be poor drug candidates for FDA approval due to their low oral bioavailability and their lack of potential profits (Vlieghe, Lisowski, Martinez, & Khrestchatisky, n.d.). Therefore alternative methods of administering the drugs have been explored in hopes of a more acceptable means rather than injecting. In this endeavor, scientist created a nasal spray of Melanotan 2 for this purpose. However, after studies were performed, it was determined that the particles of the peptide were too large to be properly absorbed through the membranes in the nasal passage rendering the drug ineffectual. Also, due to the method of ingestion, increased blood pressure and heart rate was observed in most candidates. This was not the case with candidates from the injected trials. Therefor the nasal sprays have been abandoned and sites selling them online should be avoided.
Nothing in this article is meant to be construed as legal advice nor is it an advertisement or promotion of any kind to recreationally ingest peptides. Peptides are still not FDA approved in the US and therefore it is illegal to ingest them. Any opinions provided here are for informational purposes only.
Peptides for the advancement of research can be found at the Peptide Pros Shop
ClinicalTrials.org. (n.d.). Retrieved from ClinicalTrials.org: http://clinicaltrials.gov/ct2/show/NCT01605136?term=afamelanotide&rank=8
NCBI.gov. (n.d.). Retrieved from NCBI.gov: http://www.ncbi.nlm.nih.gov/pubmed/15986465
NCBI.nlm.nih.gov. (n.d.). Retrieved from NCBI.nlm.nih.gov: http://www.ncbi.nlm.nih.gov/pubmed/15986465
Sorbitol vs. Mannitol. (n.d.). Retrieved from Livestrong.com: http://www.livestrong.com/article/521615-sorbitol-vs-mannitol/
Sunbed death not linked to banned tanning jabs. (n.d.). Retrieved from BBC.com: http://www.bbc.com/news/uk-england-lancashire-22284433
Vlieghe, P., Lisowski, V., Martinez, J., & Khrestchatisky, M. (n.d.). Synthetic Therapeutic Peptides: Science and Market. Retrieved from drugdiscoverytoday.com: http://www.drugdiscoverytoday.com/download/534