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What is Adipotide? Research Information

Product information:

  • Chemical formula – C62H98N16O22
  • Molecular weight – 1419.5


Discovery of Adipotide:

Adipotide is a revolutionary synthetic peptide that offers hope in the fight against unwanted fat cells. It was discovered in the early 2000s as part of a research program at the Scripps Research Institute in La Jolla, California. The peptide was designed to bind to a specific protein called capillary endothelial receptor-2, which is found on the surface of blood vessels that supply fat cells. Once bound, Adipotide blocks the blood supply to the fat cells, leading to their death.

Mechanism of Action:

One proposed mechanism of action is that Adipotide activates a receptor called death receptor 5 (DR5) on the surface of fat cells. Activation of DR5 leads to the initiation of a signaling pathway that ultimately leads to the death of the fat cell through a process called apoptosis. Another proposed mechanism of action is that Adipotide targets the blood vessels that supply blood to fat cells, causing them to constrict and reducing the oxygen flow and nutrients to the fat cells. Adipotide has the potential to influence essential growth factors such as angiogenesis and tissue regeneration, unlocking new pathways for healing from a variety of ailments.

Clinical Applications of Adipotide:

Adipotide’s remarkable molecular structure allows it to interact with two unique receptors found exclusively in blood vessels that provide nutrients to white fat cells. Using these exclusive ‘keys’, Adipotide can unlock the potential of a healthier body composition by targeting prohibitin and ANXA-2.

  1. Treatment of obesity: Adipotide may be used as a treatment for obesity, as it targets and destroys fat cells, which may help to reduce body weight and improve metabolic health. Adipotide is a synthetic peptide developed as a potential treatment for obesity. It has not been approved for use in clinical settings, and further research is needed to determine its safety and effectiveness.
  2. Treatment of metabolic disorders: Metabolic disorders affect how the body converts food into energy and stores it. Examples of metabolic disorders include type 2 diabetes, prediabetes, and metabolic syndrome. Adipotide may be used as a treatment for metabolic disorders in conjunction with other therapies.
  3. Treatment of lipodystrophies: Lipodystrophies are rare genetic disorders that cause abnormal body fat distribution. Symptoms of lipodystrophies can vary depending on the type and severity of the condition, but they may include abnormal fat distribution and high blood sugar levels. Adipotide may be used as a treatment for lipodystrophies in order to redistribute fat in a more normal pattern and improve metabolic health.


The information provided about Adipotide in this section is only for research advancement and disbursement of knowledge. The material collected in this article is meant for informational purposes about Adipotide. It is not to be considered instructional in any way. Moreover, we have further empathized with this by making sure no dosage information of Adipotide peptide or recommendations about its way of consumption is mentioned. The information available in this article is a collection from different recognized studies and researches conducted by known experts and researchers in controlled medical facilities and institutions. Furthermore, the information provided in the article is not to encourage the reader to start its consumption or as an advertisement of the product. Administering any supplement or medication not FDA approved may be harmful and may cause serious illness.  Peptide Pros insist that none of their products be ingested under any circumstances.


  1. Adipotide Peptide ||Sciencedaily|
  2. Prohibitin-TP01 |Wikipedia|
  3. Theiss, A. L., & Sitaraman, S. V. (2011). The role and therapeutic potential of prohibitin in disease. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research, 1813(6), 1137-1143.
  4. Mishra, S., & Nyomba, B. G. (2017). Prohibitin–At the crossroads of obesity-linked diabetes and cancer. Experimental Biology and Medicine242(11), 1170-1177.
  5. Barnhart, Kirstin F., et al. “A peptidomimetic targeting white fat causes weight loss and improved insulin resistance in obese monkeys.” Science translational medicine 3.108 (2011): 108ra112-108ra112.
  6. Kim, S. J., Miller, B., Mehta, H. H., Xiao, J., Wan, J., Arpawong, T. E., … & Cohen, P. (2019). The mitochondrial‐derived peptide MOTS‐c is a regulator of plasma metabolites and enhances insulin sensitivity. Physiological reports, 7(13), e14171.

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