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PT-141 Bremelanotide Research Information

PT-141 (Bremelanotide) Research Information

Product Description

Formerly known as PT-141, Bremelanotide is a recurrent peptide which is still being researched for a variety of benefits including female sexual dysfunction. Derived from the peptide hormone referred to as Melatonin II it was first created to be used for ‘sunless’ tanning. During studies it was discovered that, not only did Bremelanotide darken the skin but also stimulated sexual interest and arousal in women. Studies have also shown impressive results regarding the positive effects of this peptide on conditions such as reperfusion injury and hemorrhagic shock Here we will discuss Bremelanotide more extensively, discussing the details and makeup of the peptide which results in providing a variety of benefits to the human being.

PT-141 (Bremelanotide) Product Information

1.    Chemical InformationBremelanotide (PT 141) Molecular Structure

Bremelanotide contains a molecular mass of 1025.2 grams per mol. It’s chemical formula is C50H68N14O10.

2.    Systematic Name (IUPAC)

(3S 6S 9R 12S 15S)-15-[(N-acetyl-L-norleucyl)amino]- 9-bynzyl-6-{3-[(diaminomethylidine)amino]propyl}-12-(1H-imidazol-5-ylmethyl)-3-(1H-indol-3-ylmethyl)-2,5,8,11,14,17-hexaoxo-1,4,7,10,13,18-hexaa zacyclotricosane-23-carboxylic acid

3.    Pharmacokinetic and other information

Bremelanotide is currently ‘unscheduled’ by the United States government meaning that PT-141 is not regulated by law.

Bremelanotide has a half-life, or the time it takes for the compound do lose half of its potency value, is 2 hours.

Bremelanotide: The Biochemical Process

The mechanical dynamics of the PT-141 process present themselves primarily and directly to the body’s central nervous system. Specifically speaking, research involving non-human living subjects which were administered carefully monitored dosages of the peptide showed a growth in the stimulation and ‘ignition’, if you will, of the MC-4R and MC-3R melanocortin receptors themselves. This activation has led science to discover that the reaction itself actually takes control of and/or constrains particular signals emitted by the brain to the body. The signals which are inhibited are quite specific, relating to the body’s blood flow and any areas of the body experiencing inflammation. In other words, when the switch to these receptors has been flipped the brain is able to successfully moderate the signals relating to these specific issues.

Bremelanotide and Reperfusion Shock

By definition ‘reperfusion damage’ is damage caused to organ tissue which has been cut off from its blood supply by any occurrence, say a stroke for example. The damage occurs when blood flow is restored to the tissue which has been with it for so long. When tissue is deprived of the oxygen and nutrients it needs the body kicks that area into a state which can result in oxidation if blood flow is ever restored, referred to as ‘oxidative stress’. This only occurs when the body has not been eased into the healthy state properly.

The smallest of these injuries are of great detriment to the individual, as they often lead to brain injuries such as strokes or heart attacks, and can even result in complete failure of all brain function. PT-141 works on an entirely neurological level, activating the receptors which stabilize the signals sent to empower the signals related to the restriction of blood flow, easing, if not completely stopping, the chances of reperfusion shock from occurring.

Hemorrhagic Shock and PT-141 Interaction

Bremelanotide, by design, stimulates and motivates the neural reflexes within the brain, thus regulating any organic flow of blood which may cause actual organ failure which would result from actual hemorrhagic shock. Hemorrhagic shock is the result of what is referred to as a ‘lower tissue perfusion’, or the administration of oxygen to the tissue manually through a variety of methods, which invariably worsens due to increased lack of oxygen to the area over time.

There are four types, or classifications, of hemorrhagic shock:

  • Septic (or ‘vasogenic’)
  • Neurogenic
  • Hypovolemic
  • Cardiogenic

It has been proven a bit difficult to deal with this particular condition as science knows that no two individual cells demonstrate the same responses, as observed on a cellular level.


Current related research and findings regarding PT-141 (Bremelanotide)

There are some important points which should be noted regarding the study of the peptide Bremelanotide, as this substance is still in the research phase. To date all findings, theories, and conclusions have been deduced through studies done on living, non-human subjects in a completely controlled and stabilized environment. It is vehemently recommended that ANY and ALL use of PT-141 be done on a fully controlled and supervised basis ONLY.

It should also be clearly noted that a study scheduled to begin in 2007 was postponed when rises in blood pressure were found to be another side-effect, which can be dangerous in many individual cases.

Developmental information regarding Bremelanotide

Bremelanotide (PT-141) is directly derived from the peptide hormone ‘Melanotan II’. As mentioned, it was developed with full intent of marketing the product as a sunless tanning compound as it directly affected the skin-tone.

Over the course of development it was discovered to have very effective female arousal properties as well as causing erections in males on a spontaneous basis. These side-effects were not anticipated, and occurred in 90% of male subjects in the study.

In 2012 a study was conducted which administered PT-141 to premenopausal female subjects, and high-level results were reported all the way around, showing effectiveness in the treatment of a number of menopausal symptoms which had manifest, lessening them significantly.

The effects of Bremelanotide on the libido of either sex has been found to work in completely different manner when compared to enhancement drugs such as Cialis or Viagra, both of which affect blood flow to the sex organs. Rather PT-141 has been proven to stimulate sexual desire by invigorating the areas of the brain which cause sexual desire, thereby enhancing libido and performance. To date Bremelanotide has continued to be closely studied and monitored, and is currently readily available for purchase for research only at this time since it is yet to be FDA approved. Administering any supplement or medication not FDA approved may be harmful and may cause serious illness.  Peptide Pros insist that none of their products be ingested for under any circumstances.


For research purposes PT-141 (Bremelanotide) may be purchased at the Peptide Pros Shop here: