What is Raloxifene? Research Information

Discovery of RALOX:

RALOX or raloxifene is the medication that is used for the treatment and prevention of osteoporosis among women who are suffering from menopause or taking glucocorticoids. Initially, raloxifene was approved for medical purposes in the year 1997 in the united states. Ralox is available as a generic medicine. A few years back, in 2017, raloxifene was the most commonly prescribed medicine having more than 900,000 prescriptions in a single year.

Mechanism of action:

Ralox is the modulator of selective estrogen receptors, acting as an estrogen antagonist and agonist on estrogen-specific estrogen receptors. Based on findings, raloxifene has a higher binding affinity similar to estradiol. Estrogens tend to play a vital role in the different body tissues among females. Ralox mimics the action of endogenous or natural estrogen in the bone tissues. Most commonly, raloxifene is used to treat and prevent osteoporosis and corticosteroid-induced bone loss in post-menopausal women. Moreover, raloxifene also indicates a reduced risk of invasive cancer suffering from osteoporosis in the post-menopausal phase.

Clinical applications of Raloxifene:

Osteoporosis treatment and prevention:

As raloxifene is the SERM (selective estrogen receptor modulator), it tends to interact with the estrogen receptors and functions as the agonist and antagonist in different tissues at the same time. Because of the unique properties of raloxifene, it is possible to achieve the desired effects related to estrogen without stimulation of the uterus and breasts. In the case of osteoporosis, women tend to suffer from different hormonal deficiencies which mostly require hormonal therapies as the treatment. Raloxifene serves as an alternative therapy to traditional hormone replacement therapy for the treatment and prevention of osteoporosis in postmenopausal women.

Breast cancer prevention:

Invasive breast cancer is a form of cancer which is fatal and spreads to the surrounding tissue of the breasts through the milk ducts and lobules. Invasive breast cancer is the most dangerous type of cancer which requires different treatment approaches or protocols.

Another extraordinary application of raloxifene is the prevention and treatment of breast cancer in women. Raloxifene works by blocking estrogen in the breast tissues of women at a higher risk of developing it. This medication helps prevent the spread of tumors which require estrogen hormone to proliferate. According to clinical evidence, raloxifene is the best indication for treating and preventing invasive breast cancer in postmenopausal women.

Disclaimer

The information provided about Raloxifene in this section is only for research advancement and disbursement of knowledge. The material collected in this article is meant for informational purposes about Ralox. It is not to be considered instructional in any way. Moreover, we have further empathized with this by making sure no dosage information of Raloxifene or recommendations about its way of consumption is mentioned. The information available in this article is a collection from different recognized studies and researches conducted by known experts and researchers in controlled medical facilities and institutions. Furthermore, the information provided in the article is not to encourage the reader to start its consumption or as an advertisement of the product. Administering any supplement or medication not FDA approved may be harmful and may cause serious illness.  Peptide Pros insist that none of their products be ingested under any circumstances.

References:

• Raloxifene | Compound| Pubchem| Link: https://pubchem.ncbi.nlm.nih.gov/compound/Raloxifene
• Raloxifene | Compound|Chemspider| Link: http://www.chemspider.com/Chemical-Structure.4859.html
• Raloxifene | Compound| Wikipedia| Link: https://en.wikipedia.org/wiki/Raloxifene
• CiteSeerX — Defining the Role of Raloxifene for the Prevention of Breast Cancer (psu.edu)
• Khovidhunkit, W., & Shoback, D. M. (1999). Clinical effects of raloxifene hydrochloride in women. Annals of internal medicine, 130(5), 431-439.
• D’Amelio, P., & Isaia, G. C. (2013). The use of raloxifene in osteoporosis treatment. Expert opinion on pharmacotherapy, 14(7), 949-956.
• Jordan, V. C., & Morrow, M. (1999). Tamoxifen, raloxifene, and the prevention of breast cancer. Endocrine Reviews, 20(3), 253-278.

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