What is Finasteride? Research Information

Product information:

• Molecular mass – 372.55
• Chemical formula – C₂₃H₃₆N₂O₂
• Chemical name – N-tert-Butyl-3-oxo-4-aza-5α-androst-1-ene-17β-carboxamide

Other names:

• MK-906
• YM-152
• L-652,931

Discovery:

The first patent of finasteride was developed in the year 1984 and it was approved medically in the year 1992. Finasteride was developed by Merck. Merck had the initial approval from FDA in 1992 as Proscar for treating the enlarged prostate. The active ingredient of finasteride was initially useful for the treatment of hypertension and BPH (benign prostatic hyperplasia).

Mechanism of action:

Finasteride is the Type II 5α-reductase specific inhibitor, which is an intracellular enzyme capable of converting the androgen testosterone into the DHT. Among humans, the finasteride mechanism of action is based upon specific type-2 isozyme inhibition. In the human body, type-1 five alpha reductase is more prominent in the sebaceous glands, different regions of the skin, liver, and scalp. Type-one 5α-reductase is specifically responsible for the one-third circulation of DHT. For both of these isozymes, finasteride inhibition is associated with the reduction of dihydro finasteride inhibitors. Type II 5α-reductase inhibition helps in blocking the peripheral conversion of the male hormone testosterone into the DHT, which results in the significant decrease of concentrations of tissue DHT and serum.

Clinical applications:

Treatment of male pattern baldness:

This drug has specific indications for the treatment of male pattern baldness also known as androgenetic alopecia in which baldness starts at the crown and exceeds the scalp mid. The indication of finasteride is for adult men only. The mechanism behind this effect is the decrease in the DHT (natural body hormone). Decreasing the DHT concentration can lead to an increase in hair regrowth and eventually slower hair loss. Hair growth on the other body parts isn’t specifically affected by the consumption of finasteride.

Treatment of female baldness:

According to the current evidence, finasteride is approved for the treatment of FPHL (female pattern hair loss), which includes the administration of topical minoxidil. Finasteride is considered to be the specific alternative to the other treatments. Furthermore, the other therapeutic option for the treatment of female pattern baldness is a 5α-reductase inhibitor (5-ARI) along with oral dutasteride (combination). Despite the other teratogenic effects, there are several publications which are in support of the positive results of the use of FPHL.

Prevention of prostate cancer:

According to various clinical trials finasteride enhanced prostate cancer and high-grade prostate cancer diagnosis by enhancing the PSA test’s performance features.

Disclaimer

The information provided about Finasteride in this section is only for research advancement and disbursement of knowledge. The material collected in this article is meant for informational purposes about Finasteride. It is not to be considered instructional in any way. Moreover, we have further empathized with this by making sure no dosage information of Finasteride or recommendations about its way of consumption is mentioned. The information available in this article is a collection from different recognized studies and researches conducted by known experts and researchers in controlled medical facilities and institutions. Furthermore, the information provided in the article is not to encourage the reader to start its consumption or as an advertisement of the product. Administering any supplement or medication not FDA approved may be harmful and may cause serious illness.  Peptide Pros insist that none of their products be ingested under any circumstances.

References:

1. Finasteride |C23H36N2O2| Wikipedia Link: https://en.wikipedia.org/wiki/Finasteride
2. Finn, D. A., Beadles‐Bohling, A. S., Beckley, E. H., Ford, M. M., Gililland, K. R., Gorin‐Meyer, R. E., & Wiren, K. M. (2006). A new look at the 5α‐reductase inhibitor finasteride. CNS drug reviews, 12(1), 53-76.
3. Iamsumang, W., Leerunyakul, K., & Suchonwanit, P. (2020). Finasteride and its potential for the treatment of female pattern hair loss: evidence to date. Drug Design, Development and Therapy, 14, 951.
4. Hamilton, R. J., Kahwati, L. C., & Kinsinger, L. S. (2010). Knowledge and use of finasteride for the prevention of prostate cancer. Cancer epidemiology, biomarkers & prevention, 19(9), 2164-2171.
5. Gormley, G. J. (1995). Finasteride: a clinical review. Biomedicine & pharmacotherapy, 49(7-8), 319-324.

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