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What is Yohimbine HCL? Research Information

Product information:

  • Molecular formula –   C21H27ClN203
  • Molecular mass  –       390.9g/mol

Other names:

  • Yohimbine HCl
  • HCL Yohimbine
  • Antagonil
  • Yohimbe
  • Aphrodine hydrochloride
  • Yohimbine monohydrochloride


Yohimbine is a unique alkaloid discovered in 1934 by an American botanist, R. Raymond-Hamet. Originating from two African and Indian herbs – Yohimbe bark and snakeroot, it has been used for centuries as a traditional aphrodisiac. Yohimbine hydrochloride was subsequently synthesized, and its pharmacological properties were extensively studied. Yohimbine hydrochloride is an effective treatment for impotence that has been approved by the FDA.

Mechanism of action:

Yohimbine  exerts its effects by blocking presynaptic alpha-2 adrenergic receptors. This results in increased parasympathetic activity and decreased sympathetic stimulation, leading to increased blood flow and relaxation of smooth muscles in the penis, which is important for the treatment of erectile dysfunction. Yohimbine HCL also affects two neurotransmitters, norepinephrine, and serotonin. Norepinephrine increases metabolic rate, while serotonin reduces appetite. Yohimbine’s ability to block alpha-2 adrenergic receptors located in fat cells is also believed to lead to increased fat loss and weight loss.

Clinical Applications of Yohimbine HCL

Yohimbine HCL is an alkaloid derived from the bark of the Yohimbe tree and has many proven medical applications.

Erectile Dysfunction Treatment

Perhaps one of the most well-known uses for Yohimbine HCL is treating erectile dysfunction (ED) in men. Its mechanism of action involves blocking alpha-2 adrenergic receptors, leading to an increase in sympathetic activity and a decrease in parasympathetic tone. This results in the dilation of blood vessels and an increase in blood flow to the penis, which is essential for achieving and maintaining an erection.

Additionally, Yohimbe has been shown to increase the activity of the sympathetic nervous system, which can enhance sexual arousal and improve sexual function. It also has mild anti-anxiety effects, which can be beneficial for individuals experiencing performance anxiety or other psychological factors contributing to their ED. However, several studies suggested that the aphrodisiac effects of the extract were only a placebo or due to the increase in peripheral vascular congestion. In contrast, other studies reported that it could provide excellent curative effects on organic impotence.

It is important to note that the evidence for yohimbine’s effectiveness as a treatment for ED is mixed, and more research is needed.

Weight Loss

Yohimbine, an alpha 2-receptor antagonist, has also been known to reduce appetite and help those trying to lose weight. Some studies show taking Yohimbine before meals may help decrease hunger cravings and contribute to successful weight loss efforts when combined with a healthy diet and exercise plan. It affects two neurotransmitters in particular – norepinephrine (which increases metabolic rate) and serotonin (which reduces appetite).

While some studies evaluated that Yohimbine’s ability to block the alpha-2 adrenergic receptors located in fat cells could lead to increased fat loss and weight loss; other studies didn’t find a significant effect on the placebo group.


The information provided about Yohimbine HCL in this section is only for research advancement and disbursement of knowledge. The material collected in this article is meant for informational purposes about Yohimbine. It is not to be considered instructional in any way. Moreover, we have further empathized with this by making sure no dosage information of Yohimbine or recommendations about its way of consumption is mentioned. The information available in this article is a collection from different recognized studies and researches conducted by known experts and researchers in controlled medical facilities and institutions. Furthermore, the information provided in the article is not to encourage the reader to start its consumption or as an advertisement of the product. Administering any supplement or medication not FDA approved may be harmful and may cause serious illness.  Peptide Pros insist that none of their products be ingested under any circumstances.


  2. Jabir, N. R., Firoz, C. K., Zughaibi, T. A., Alsaadi, M. A., Abuzenadah, A. M., Al-Asmari, A. I., … & Tabrez, S. (2022). A literature perspective on the pharmacological applications of yohimbine. Annals of Medicine54(1), 2861-2875.
  3. Riley, A. J., Goodman, R. E., Kellett, J. M., & Orr, R. (1989). Double blind trial of yohimbine hydrochloride in the treatment of erection inadequacy. Sexual and Marital Therapy4(1), 17-26.
  4. Lebret, T., Hervé, J. M., Gorny, P., Worcel, M., & Botto, H. (2002). Efficacy and safety of a novel combination of L-arginine glutamate and yohimbine hydrochloride: a new oral therapy for erectile dysfunction. European urology, 41(6), 608-613.
  5.  Yohimbe |Healthline|,an%20effective%20weight%20loss%20supplement.

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