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What is Vardenafil? Research Information

Product information:

  • Molecular formula – C29H40N6O11S
  • Molecular mass – 680.7 g/mol

Other names:

  • DSSTox_CID_26696
  • 224789-15-5
  • DSSTox_RID_81830
  • Vardenafil Dihydrochloride Salt
  • DSSTox_GSID_46696
  • NCGC00167533-01
  • CAS-1193386-64-9
  • 224V155
  • NC00357
  • CCG-101107
  • SMR000469155
  • NCGC00167533-02

Discovery of Vardenafil Citrate:

In the year 2003, two significant PDE5 inhibitors were discovered, which were known as Vardenafil and tadalafil. Both drugs were approved by the FDA for different medical purposes. This drug was co-marketed by different companies such as Schering-Plough, GlaxoSmithKline, and Bayer Pharmaceuticals.  The most significant indication of these two drugs was the treatment of male erectile dysfunction.

Mechanism of action of Vardenafil Citrate:

Vardenafil Citrate is the selective PDE5 (phosphodiesterase type-5) inhibitor, which is used as a significant therapy for erectile dysfunction. Vardenafil Citrate is also a benzene sulfonamide derivative, which inhibits the PDE5 along with the vasodilator properties.

Vardenafil Citrate selectively inhibits the PDE5, as a result, it inhibits the cGMP (cyclic guanosine monophosphate) degradation, which is found in the smooth muscles of corpus spongiosum and corpus cavernosa in the penis. The cGMP degradation inhibition results in the prolonged vasodilation and relaxation of the penile muscles. As a result of vasodilation, blood engagement and blood flow to the penis increase, which in turn increases the erection of the penis.

Clinical applications of Vardenafil Citrate:

Sexual dysfunction:

Vardenafil and several other PDE5 inhibitors work for the treatment of erectile dysfunction by allowing a better flow of blood to the penis. For understanding the action of Vardenafil Citrate for sexual dysfunction, you need to understand the process of erection which is:

  • When a man becomes sexually aroused, the brain tends to send a signal to the blood vessels present in the penile area to stimulate the release of a chemical known as nitric oxide. This nitric oxide diffuses inside the vasculature of the penis to stimulate the formation of another molecule known as cGMP. The cGMP helps in relaxing the blood vessels of the penis to allow even more flow of blood inside.

In some men, it is difficult to achieve an erection even when they are sexually aroused. In such cases, the cGMP is broken down by the PDE5 enzyme to not achieve the relaxation of penile smooth muscles. Vardenafil Citrate inhibits the PDE5 enzyme, which causes the breakdown of cGMP. Inhibition of this enzyme results in increasing the amount of cGMP present in the blood vessels and also facilitates the entry of the blood inside.

Along with treating erectile dysfunction, some PDE5 inhibitors are also in use for the treatment of a medical condition such as pulmonary hypertension.


The information provided about Vardenafil in this section is only for research advancement and disbursement of knowledge. The material collected in this article is meant for informational purposes about Vardenafil Citrate. It is not to be considered instructional in any way. Moreover, we have further empathized with this by making sure no dosage information of Vardenafil or recommendations about its way of consumption is mentioned. The information available in this article is a collection from different recognized studies and researches conducted by known experts and researchers in controlled medical facilities and institutions. Furthermore, the information provided in the article is not to encourage the reader to start its consumption or as an advertisement of the product. Administering any supplement or medication not FDA approved may be harmful and may cause serious illness.  Peptide Pros insist that none of their products be ingested under any circumstances.


  • Vardenafil |DB00862| Link:
  • Vardenafil | 135400189| Pubchem
  • Neumeyer, K., & Kirkpatrick, P. (2004). Tadalafil and vardenafil. Nature reviews. Drug discovery3(4), 295.
  • Gresser, U., & Gleiter, C. H. (2002). Erectile dysfunction: comparison of efficacy and side effects of the PDE-5 inhibitors sildenafil, vardenafil and tadalafil-review of the literature. European journal of medical research7(10), 435-446.
  • Markou, S., Perimenis, P., Gyftopoulos, K., Athanasopoulos, A., & Barbalias, G. (2004). Vardenafil (Levitra) for erectile dysfunction: a systematic review and meta-analysis of clinical trial reports. International journal of impotence research16(6), 470-478.
  • Hellstrom, W. J., Gittelman, M., Karlin, G., Segerson, T., Thibonnier, M., Taylor, T., & PADMA‐NATHAN, H. A. R. I. N. (2002). Vardenafil for treatment of men with erectile dysfunction: Efficacy and safety in a randomized, double‐blind, placebo‐controlled trial. Journal of andrology23(6), 763-771.

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