- Molecular formula – C25H22O10
- Molecular weight – 482.4 g/mol
- Silymarine I
- Flavobin Spofa
- Silybin;Silibinin A;Silymarin I
Discovery of Silymarin:
Silymarin is an antioxidant which is taken from the seeds of the milk thistle. A Greek botanist and physician Dioscorides was the first one to describe the healing properties of milk thistle in 40-90 AD. Later on, in the year 1597, another scientist John Gerard noticed the efficacy of Silymarin and milk thistle for different diseases and their best treatments.
Mechanism of action of Silymarin:
Silymarin has both regenerative and hepatoprotective actions inside the human body. The mechanism of action of silymarin is the reduction of FR, which is formed by toxins (these toxins damage the membranes of the cells). Moreover, silymarin also does competitive inhibition through the modification of the hepatocyte external cell membranes.
Silymarin tends to act as the free radical scavenger which modulates the enzymes associated with the development of cirrhosis, fibrosis, and cellular damage. The hepatoprotective effects of silymarin were observed in different clinical studies in patients with non-alcoholic and alcoholic fatty liver diseases, including patients with fibrosis and cirrhosis.
Clinical applications of Silymarin:
Silymarin and liver diseases:
There is plenty of research on the benefits of milk thistle or silymarin for liver health. Silymarin has several protective effects on liver health to prevent and protect the damage.
According to some evidence, silymarin can treat patients with chronic hepatitis and cirrhosis, which can be due to viruses, autoimmune diseases, and alcohol abuse. Silymarin has cell-regulating and metabolic effects, which result in the inhibition of the 5-lipoxygenase pathway to decrease the concentration of ROS (reactive oxygen species) on the DNA expression through the NF-kB nuclear factor suppression.
As per the clinical investigations, silymarin can help with liver damage caused by industrial toxins such as xylene and toluene.
Silymarin – a potent antioxidant:
All aerobic organisms have several antioxidant defences for removing and repairing damaged molecules. Antioxidant compounds can help in scavenging the concentration of free radicals and increasing the shelf life by retarding the lipid peroxidation process (the main reason for pharmaceutical and food products).
Silymarin acts as a potent antioxidant to deal with the damage occurring in the body. Antioxidants can prevent the radical chain reaction of oxidation, causing the delay or termination of the oxidation process. According to the clinical data, silymarin has several hepatoprotection, anti-inflammatory, vasodilatory, antithrombotic, antineoplastic, antiviral, antiallergic, antibacterial, and antimutagenic properties.
The information provided about Silymarin in this section is only for research advancement and disbursement of knowledge. The material collected in this article is meant for informational purposes about Silymarin. It is not to be considered instructional in any way. Moreover, we have further empathized with this by making sure no dosage information of Silymarin or recommendations about its way of consumption is mentioned. The information available in this article is a collection from different recognized studies and researches conducted by known experts and researchers in controlled medical facilities and institutions. Furthermore, the information provided in the article is not to encourage the reader to start its consumption or as an advertisement of the product. Administering any supplement or medication not FDA approved may be harmful and may cause serious illness. Peptide Pros insist that none of their products be ingested under any circumstances.
- Silibinin |DB09298| https://go.drugbank.com/drugs/DB09298
- Silybin |Pubchem| https://pubchem.ncbi.nlm.nih.gov/compound/Silymarin
- Bijak, Michal. “Silybin, a major bioactive component of milk thistle (Silybum marianum L. Gaernt.)—Chemistry, bioavailability, and metabolism.” Molecules 22.11 (2017): 1942.
- Fraschini, F., Demartini, G., & Esposti, D. (2002). Pharmacology of silymarin. Clinical drug investigation, 22(1), 51-65.
- KÖksal, E., Gülçin, I., Beyza, S., Sarikaya, O., & Bursal, E. (2009). In vitro antioxidant activity of silymarin. Journal of enzyme inhibition and medicinal chemistry, 24(2), 395-405.
- Gillessen, A., & Schmidt, H. H. J. (2020). Silymarin as supportive treatment in liver diseases: A narrative review. Advances in therapy, 37(4), 1279-1301.
- Saller, R., Meier, R., & Brignoli, R. (2001). The use of silymarin in the treatment of liver diseases. Drugs, 61(14), 2035-2063.
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