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What is Sildenafil? Research Information
Product information:
- Chemical formula – C22H30N6O4S
- Molecular weight – 474.6 g/mol
- Acting time – 20 minutes
- Half-life – 3.5 to 4 hours
Other names:
- 5-[2-ethoxy-5-(4-methylpiperazin-1-yl) sulfonyl phenyl]-1-methyl-3-propyl-6H-pyrazolo[4,3-d] pyrimidin-7-one
- UK-92480
- VIAGRA
- 139755-83-2
- UNII-3M7OB98Y7H
- 1-((3-(4,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo(4,3-d) pyrimidin-5-yl)-4-ethoxyphenyl) sulfonyl)-4-methylpiperazine
Discovery of Sildenafil:
The Pfizer company developed Sildenafil compound for hypertension treatment and problems of angina pectoris as chest pain. During the clinical trials of the sildenafil, researchers found that this drug had more effectiveness for inducing male erections and treating erectile dysfunctions.
In the year 1998, the FDA approved Sildenafil Citrate for sexual dysfunctions like erectile dysfunction.
By the year 2008, the distribution of sidenafil reached about two billion dollars worldwide, and since then, it has kept on increasing.
Mechanism of action:
The mechanism of action of sildenafil is based on enhancing the effect of NO by inhibiting PDE5 (phosphodiesterase type-5), which is a causing agent for cGMP degradation in corpus cavernosum. When NO is released as a local response to sexual stimulation, PDE5 inhibition causes an increase in the cGMP levels. This phenomenon results in the relaxation of smooth muscles and the flow of blood inside the corpus cavernosum.
In response to sexual stimulation, the natural response of the men is the erectile penis, but in erectile dysfunction, men are unable to erect their penis. Sildenafil Citrate controls the body’s enzymes, which help keep the penis erect when stroked or stimulated.
Clinical applications of sildenafil:
Erection problems:
According to a dose-response study, a gradual increase in the dosage of sildenafil can improve erectile dysfunction. The study also showed that the men receiving a constant dosage for the whole 4-weeks had 100% improvement in their erectile dysfunction. The research says Sildenfil has very low side effects as compared to other treatments.
Pulmonary hypertension:
Pulmonary hypertension is the fatal disease of neonates, which accounts for most of the deaths in neonates as well. In the PH, individuals or infants have less concentration of nitric oxide. Inhaled nitric oxide assists in the ventilation and treatment of the disease, but it is less appropriate for patients who are sensitive to it. High phosphodiesterase concentrations in pulmonary vessels can cause blockage, which requires sildenafil or PDE5-inhibitors.
Disclaimer:
The information provided about Sildenafil Citrate in this section is only for the purpose of research advancement and disbursement of knowledge. The material collected in this article is meant for informational purposes about citrate sildenafil and is not to be considered instructional in any way. Moreover, we have further empathized with this by making sure no dosage information of Sildenafil Citrate or recommendations about its way of consumption are mentioned. The information available in this article is a collection from different recognized studies and researches conducted by known experts and researchers in controlled medical facilities and institutions. Furthermore, the information provided in the article is not to encourage the reader to start its consumption or as an advertisement of the product. Administering any supplement or medication not FDA approved may be harmful and may cause serious illness. Peptide Pros insist that none of their products be ingested under any circumstances.
References:
- Sildenafil | C22H30N6O4S| ChemSpider. (n.d.). ChemSpider | http://www.chemspider.com/Chemical-Structure.5023.html
- Viagra |Sildenafil | FDA |History.com
- Wang, J., J. Re, and Z. Wang. “Mode of action of sildenafil.” Zhongguo yi xue ke xue Yuan xue bao. Acta Academiae Medicinae Sinicae 21.6 (1999): 493-496.
- Shah, P. S., & Ohlsson, A. (2011). Sildenafil for pulmonary hypertension in neonates. Cochrane Database of Systematic Reviews.
- Lee, A. J., Chiao, T. B., & Tsang, M. P. (2005). Sildenafil for pulmonary hypertension. Annals of Pharmacotherapy, 39(5), 869-884.
- Salonia, A., Rigatti, P., & Montorsi, F. (2003). Sildenafil in erectile dysfunction: a critical review. Current medical research and opinion, 19(4), 241-262.
- Goldstein, I., Lue, T. F., Padma-Nathan, H., Rosen, R. C., Steers, W. D., & Wicker, P. A. (1998). Oral sildenafil in the treatment of erectile dysfunction. New England Journal of Medicine, 338(20), 1397-1404.
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