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What is SEMAX? Research Information

Product information:

  • Molecular formula – C37H51N9O10S
  • Molecular mass – 813.9 g·mol−1
  • Groups – FDA Approved


  • 80714-61-0
  • ACTH (4-7), Pro-Gly-Pro-
  • I5FAL2585H
  • Met-Glu-His-Phe-Pro-Gly-Pro
  • SEMAX peptide


SEMAX belongs to the class of neuropeptides. It was developed by the Institute of Molecular Genetics in Russia. The research for the discovery of SEMAX included over 30 scientists from various fields of neurology. These scientists focused on a small segment of the adrenocorticotropic hormone, Pro8-Gly9-Pro10ACTH(4-10). The focus was also placed on dissociating several amino acids, substituting, and linking peptides. All of these combined had unique neuroregulatory properties.

After extensive research over 14 years, the Russian Federal Ministry approved using SEMAX as a neuroactive peptide. This unique molecule has several beneficial neurological functions that help improve cognitive functions.   

Mechanism of action:

SEMAX peptide is the synthetic form of ACTH. The mechanism of action of SEMAX is similar to ACTH. It helps elevate the brain-derived neurotrophic factor (BDNF) and the signaling receptor TrkB in the hippocampus. Additionally, it helps activate serotonergic and dopaminergic systems in the brain.

The exact pharmacological mechanism of action is not clear. However, there is evidence that it acts through the melanocortin receptors. According to this research, SEMAX may act as a partial agonist or antagonist of MC4 and MC5 receptors of the α-melanocyte-stimulating hormone

Clinical  Applications of SEMAX:

  1. Attention Deficit Hyperactivity Disorder and Rett Syndrome

Attention deficit hyperactivity disorder is a condition that is characterized by hyperactivity, inattention, and impulsivity. It is very commonly found in children. Psychostimulants are the most common form of treatment for patients with ADHD. SEMAX helps in the stimulation of memory and attention after being applied intranasally. This is why this drug has positive therapeutic effects on ADHD and Rett syndrome. SEMAX helps stimulate the brain-derived neurotrophic factor (BDNF), which is essential in improving a severe neurodevelopmental disorder.

  • Analgesic Effect

Studies show that SEMAX helps reduce pain sensitivity after peritoneal administration. However, this effect was more potent when the drug was administered intranasally. SEMAX helps relieve migraines, headaches, and pain due to dental plexalgia.

  • Ischemic Stroke

SEMAX is the first nootropic drug that displays multiple functions, which studies have proved. The experimental research shows it possesses Angio protective, anti-hypoxic, and neurotrophic activity. It is efficient in acute ischemic stroke. This drug influences the anti-inflammatory postischemic reaction of the brain.  


The information provided about SEMAX in this section is only for research advancement and disbursement of knowledge. The material collected in this article is meant for informational purposes about SEMAX . It is not to be considered instructional in any way. Moreover, we have further empathized with this by making sure no dosage information of SEMAX peptide or recommendations about its way of consumption is mentioned. The information available in this article is a collection from different recognized studies and researches conducted by known experts and researchers in controlled medical facilities and institutions. Furthermore, the information provided in the article is not to encourage the reader to start its consumption or as an advertisement of the product. Administering any supplement or medication not FDA approved may be harmful and may cause serious illness.  Peptide Pros insist that none of their products be ingested under any circumstances.


  1. Semax|C37H51N9O10S| Pubchem|
  2. Semax |Semaxint|
  3. Medvedeva, E. V., Dmitrieva, V. G., Povarova, O. V., Limborska, S. A., Skvortsova, V. I., Myasoedov, N. F., & Dergunova, L. V. (2014). The peptide semax affects the expression of genes related to the immune and vascular systems in rat brain focal ischemia: genome-wide transcriptional analysis. BMC genomics, 15, 1-12.
  4. Dolotov, O. V., Karpenko, E. A., Inozemtseva, L. S., Seredenina, T. S., Levitskaya, N. G., Rozyczka, J., … & Engele, J. (2006). Semax, an analog of ACTH (4–10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus. Brain research, 1117(1), 54-60.
  5. Koroleva, M. V., Meizerov, E. E., Nezavibat’ko, V. N., Kamenskii, A. A., Dubynin, V. A., & Yakovlev, Y. B. (1996). Analgesic action of the new drug Semax. Bulletin of experimental biology and medicine, 122, 1107-1109.
  6. Miasoedova, N. F., Skvortsova, V. I., Nasonov, E. L., EIu, Z., Grivennikov, I. A., Arsen’eva, E. L., & Sukhanov, I. I. (1999). Investigation of mechanisms of neuro-protective effect of semax in acute period of ischemic stroke. Zhurnal nevrologii i psikhiatrii imeni SS Korsakova, 99(5), 15-19.

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