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What is Myostatin? Research Information

Product information:

Chemical formula – C1100H1646O314N294S24

Molecular weight –  42749.8

Other names:

  • GDF-8
  • GDF8
  • Myostatin
  • MSTN

Discovery of  Myostatin HMP:

 Myostatin was discovered in 1997 by geneticists Se-Jin Lee and Alexandra McPherron.

Myostatin HMP was referred to as growth/differentiation factor-8 (GDF-8). This GDF-8 expresses itself in adult animals and is widespread across the entire muscle mass. The experiment performed showed that myostatin HMP is a regulator of skeletal muscle growth.

Mechanism of Action

Myostatin works by binding to activin type II receptors. This results in the signaling to either Alk-3 or Alk-4. Either of these coreceptors then starts a signaling cascade. The signaling cascade in the muscles results in the activation of the SMAD family. SMAD family includes transcription factors SMAD3 and SMAD2. It is because of these factors that myostatin produces its specific functions. Examples include gene regulation, breakdown of muscle protein, or even protein degradation.

Clinical Applications of Myostatin HMP:

The most common indications include:

Regulation of fat and Mass

The basic and primary function of myostatin is observed in muscle tissues. Researchers have identified that this compound helps in the negative regulation of muscle tissues. Because of this effect, the double muscle trait in cattle became popular. Myostatin can produce a double effect on mammals. It can control the body fat mass. Additionally, it also helps in the promotion of adipogenesis.

Cardiac Development

Myostatin may play a role in heart failure and reverse remodeling after LVAD support. The role of myostatin in cardiac development after experiment on fetal as well as baby sheep have proved this theory. Because of this reason, myostatin may be helpful in heart failure, hypertrophy, and fibrosis.

Cardiac MRI in experiments showed that inactivating myostatin resulted in cardiac hypertrophy as well as heart failure. This is because myostatin causes repression of AMP-activated kinase in the heart. Thereby, preventing the switch between glycolysis as well as glycogen accumulation. Therefore, it can be concluded that myostatin is essential for maintaining cardiac energy and preventing cardiac hypertrophy.

Regulates Energy Homeostasis

Myostatin regulates energy homeostasis in the heart and prevents heart failure. Atrophy of muscle cells results in loss of function and waste of muscle fibers. Skeletal muscle homeostasis is very important to balance function. It helps in the regulation of stem cell activation. Additionally, it also promotes the survival of muscle syncitia. Therefore, researchers have found that dogs with at least one myostatin gene have enhanced performance.

Disclaimer:

The information provided about Myostatin HMP in this section is only for research and disbursement of knowledge. The material collected in this article is meant for informational purposes about Myostatin and is not to be considered instructional in any way. Moreover, we have further empathized with this by making sure no dosage information of Myostatin or recommendations about its consumption are mentioned. The information available in this article is a collection from different recognized studies and researches conducted by known experts and researchers in controlled medical facilities and institutions. Furthermore, the information provided in the article is not to encourage the reader to start its consumption or as an advertisement of the product.  Administering any supplement or medication not FDA approved may be harmful and cause serious illness. Peptide Pros insist that none of their products be ingested under any circumstances.

References:

  1. Myostatin | GDF8|drugs.ncats.io|Link: https://drugs.ncats.io/substance/6O86C0ZH33
  2. Myostatin | GDF8| Wikipedia Link: https://en.wikipedia.org/wiki/Myostatin
  3. Aiello, D., K. Patel, and E. Lasagna. “The myostatin gene: an overview of mechanisms of action and its relevance to livestock animals.” Animal genetics 49.6 (2018): 505-519.
  4. Deng, Bing, et al. “The function of myostatin in the regulation of fat mass in mammals.” Nutrition & metabolism 14.1 (2017): 1-6.
  5. George, Isaac, et al. “Myostatin activation in patients with advanced heart failure and after mechanical unloading.” European journal of heart failure 12.5 (2010): 444-453.
  6. Biesemann, Nadine, et al. “Myostatin regulates energy homeostasis in the heart and prevents heart failure.” Circulation research 115.2 (2014): 296-310.

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