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What is MK-677? Research Information

Product information:

MK 677, also known as Ibutamoren, is a highly potent, orally active growth hormone secretagogue that mimics the growth hormone (GH)-stimulating action of the endogenous hormone ghrelin. Clinically, MK-677 has been demonstrated to increase the secretion of several hormones including growth hormones (GH) and insulin like growth factor 1 (IGF-1) without affecting prolactin and cortisol levels.

Other Names:

  • MK-677
  • L-163,191
  • Oratrope
  • Ibutamoren mesylate
  • Ibutamoren mesylate
  • Crescendo
  • UNII-R90JB6QJ2B

Chemical structure:

  • Molecular formula – 28H40N4O8S2
  • Molecular weight – 624.8
MK-677 Chemical Structure

Discovery:

MK-677 was first developed in the year 1995. Merck develops MK-667 in the United States of America

The discovery of MK-677 was as a “secretagogue” for growth hormones. These compounds have the best results as an alternative to growth hormone replacement therapy. A reduction-based/Fischer indole strategy provides the novel nucleus (Spiroindoline) of this compound.

Mechanism of action:

MK-677 or Ibutamoren is a selective, long-acting, non-peptide, and potent agonist for ghrelin receptors. In addition, this compound is a growth hormone secretagogue that mimics the action of GH (growth hormone) for producing endogenous hormones.

MK-677 has the potent capability to sustain the IGF-1 and GH activation. Moreover, this compound can also increase the lean body mass without changing the body’s visceral fat or total fat mass.

Proposed application. Clinical trials of MK-677:

  1. Reversal of diet-induced catabolism:

According to a clinical trial on oral MK-677, the following findings showed:

  • MK-677 improved the balance of nitrogen over the treatment of seven days
  • The mean of IGF binding proteins increased with the dosage of MK-677 for the last five days of the trial.
  • MK-677 reversed the wasting of nitrogen (diet-induced) which suggests that this compound is beneficial for treating short-term anabolic effects. However, these problems persist due to any chronic or acute disease.
MK 677 Research Information
Changes in serum IGF-I concentrations during this clinical trial. MK-677 (▪) and placebo (○) were administered, and blood samples obtained as described in the subjects and methods of the trial . Results are mean ± SD for eight subjects. Compared with control period, increases in serum IGF-I concentrations obtained during MK-677 treatment were significant (P < 0.05).

2. Obesity Treatment Clinical Trial:

According to the results of the clinical trial it was reported:

  • Levels of serum insulin-like growth factors increased about 40%
  • Levels of serum Insulin growth factor 1 proteins also increased
  • Fat-free muscle mass significantly increased

As per 2 months clinical research “Changes in body composition and energy expenditure were of an anabolic nature, with a sustained increase in fat-free mass and a transient increase in basal metabolic rate. Further studies are needed to evaluate whether a higher dose of MK-677 or a more prolonged treatment period can promote a reduction in body fat.”

3. Sleep Quality Research:

According to another clinical trial, the dosage of MK-677 is effective for improving sleep patterns and it’s quality.

The findings of the research study showed:

  • MK-677 helps to increase the stage-IV duration of sleep (50%)
  • It can also improve REM sleep by 20%.
  • MK-677 can improve sleep quality and help in the correction of relative somatopause.

Disclaimer:

The information provided about MK-677 in this section is only for the purpose of research advancement and disbursement of knowledge. The material collected in this article is meant for informational purposes and is not to be considered instructional in any way. Moreover, we have further empathized with this by making sure no dosage information of MK-677 or recommendations about its way of consumption are mentioned. The information available in this article is a collection from different recognized studies and researches conducted by known experts and researchers in controlled medical facilities and institutions. Furthermore, the information provided in the article is not to encourage the reader to start its consumption or as an advertisement of the product. Administering any supplement or medication not FDA approved may be harmful and may cause serious illness.  Peptide Pros insist that none of their products be ingested under any circumstances.

Sources:

Lee J, Kwon A, Chae HW, Lee WJ, Kim TH, Kim HS. Effect of the Orally Active Growth Hormone Secretagogue MK-677 on Somatic Growth in Rats. Yonsei medical journal. 2018 Dec 1;59(10):1174.

Murphy MG, Plunkett LM, Gertz BJ, He W, Wittreich J, Polvino WM, Clemmons DR. MK-677, an orally active growth hormone secretagogue, reverses diet-induced catabolism. The Journal of Clinical Endocrinology & Metabolism. 1998 Feb 1;83(2):320-5.

Sorbera LA, Bolos J, Serradell N. Ibutamoren Mesylate.

Svensson J, Lonn L, Jansson JO, Murphy G, Wyss D, Krupa D, Cerchio K, Polvino W, Gertz B, Boseaus I, Sjostrom L. Two-month treatment of obese subjects with the oral growth hormone (GH) secretagogue MK-677 increases GH secretion, fat-free mass, and energy expenditure. The Journal of Clinical Endocrinology & Metabolism. 1998 Feb 1;83(2):362-9.

Copinschi G, Leproult R, Van Onderbergen A, Caufriez A, Cole KY, Schilling LM, Mendel CM, De Lepeleire I, Bolognese JA, Van Cauter E. Prolonged oral treatment with MK-677, a novel growth hormone secretagogue, improves sleep quality in man. Neuroendocrinology. 1997;66(4):278-86.

Maligres PE, Houpis I, Rossen K, Molina A, Sager J, Upadhyay V, Wells KM, Reamer RA, Lynch JE, Askin D, Volante RP. Synthesis of the orally active spiroindoline-based growth hormone secretagogue, MK-677. Tetrahedron. 1997 Aug 11;53(32):10983-92.

Murphy MG, Bach MA, Plotkin D, Bolognese J, Ng J, Krupa D, Cerchio K, Gertz BJ. Oral Administration of the growth hormone secretagogue MK‐677 increases markers of bone turnover in healthy and functionally impaired elderly adults. Journal of bone and mineral research. 1999 Jul;14(7):1182-8.

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