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Ipamorelin Research Information

What is Ipamorelin? Research Information

Product information:

  • Molecular formula – C38H49N9O5
  • Molecular weight –  711.9

Other names:

  • NNC 26-0161
  • (2S)-6-amino-2-[(2R)-2-[(2R)-2-[(2S)-2-(2-amino-2-methylpropanamido)-3-(1H-imidazol-4-yl)propanamido]-3-(naphthalen-2-yl)propanamido]-3-phenylpropanamido]hexanamide
Ipamorelin Peptide

Discovery:

Ipamorelin is widely being tested for age management, disease management, sports performance, and GH deficit therapy regimens. It is theoretically one of the safest and most effective ways to restore growth hormone (GH). Helsinn Therapeutics researched ipamorelin in phase II clinical trials to treat postoperative ileus, which Novo Nordisk originally developed.

Mechanism of action:

Because the peptide is an endogenous hormone that behaves similarly to Ghrelin, the mode of action is biomimicry. It is more stable in inhibiting the effects of somatostatin and releasing growth hormone at a steady rate than growth hormone-releasing hexapeptide.

Ipamorelin is a pentapeptide, which comprises 5 amino acids that replicate the body’s normal growth hormone release. Ipamorelin is a GHRP that functions as a Ghrelin analog. By inhibiting somatostatin, it stimulates GH release and increases the number of somatotrophs (cells responsible for GH release) in a GH pulse.

Results from various studies and trials utilizing Ipamorelin includes:

  • Reduction in body fat
  • Improved muscle strength and mass
  • Strengthened bones
  • Repaired joints and ligaments
  • Improved skin quality
  • Increased energy and vitality

Clinical applications:

Performance enhancement:

In human clinical trials on volunteers, Ipamorelin peptide has shown promising results. Ipamorelin is one of the safest and most successful ways to restore growth hormone (GH), and it’s widely utilized in age management, disease management, sports performance, and GH deficit treatment regimens.

Postoperative ileus:

Ghrelin and ghrelin mimetics increase stomach motility and boost appetite. This study focused on finding if ipamorelin, a selective growth hormone secretagogue and ghrelin receptor agonist, can speed up gastrointestinal transit and alleviate symptoms in a rodent model of postoperative ileus.

Improved muscle strength and mass

According to studies Ipamorelin helps develop lean muscle mass, enhance strength, and reduce body fat by boosting the generation and secretion of GH. Ipamorelin boosts fat metabolism, which can help you lose weight and improve your body composition.

Disclaimer:

The information provided about peptide Ipamorelin in this section is only for research and disbursement of knowledge. The material collected in this article is meant for informational purposes about Ipamorelin peptide and is not to be considered instructional in any way. Moreover, we have further empathized with this by making sure no dosage information of Ipamorelin Peptide or recommendations about its consumption are mentioned. The information available in this article is a collection from different recognized studies and researches conducted by known experts and researchers in controlled medical facilities and institutions. Furthermore, the information provided in the article is not to encourage the reader to start its consumption or as an advertisement of the product.  Administering any supplement or medication not FDA approved may be harmful and cause serious illness. Peptide Pros insist that none of their products be ingested under any circumstances.

References:

  1. Ipamorelin | C38H49N9O5| Pubchem. (n.d.). Pubchem|

https://pubchem.ncbi.nlm.nih.gov/compound/Ipamorelin

  •  Ipamorelin | Growth Hormone Secretagogue |Wikipedia.com

https://en.wikipedia.org/wiki/Ipamorelin

  • Ipamorelin | DB12370 |drugbank|

https://go.drugbank.com/drugs/DB12370

  • Gobburu, Jogarao VS, et al. “Pharmacokinetic-pharmacodynamic modeling of ipamorelin, a growth hormone releasing peptide, in human volunteers.” Pharmaceutical research 16.9 (1999): 1412-1416.
  • Raun, Kirsten, et al. “Ipamorelin, the first selective growth hormone secretagogue.” European journal of endocrinology 139.5 (1998): 552-561.
  • Venkova, Kalina, et al. “Efficacy of ipamorelin, a novel ghrelin mimetic, in a rodent model of postoperative ileus.” Journal of pharmacology and experimental therapeutics 329.3 (2009): 1110-1116.
  • Handelsman, David J. “Performance enhancing hormone doping in sport.” Endotext [Internet] (2020).

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