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What is IGF-1 DES? Research Information


Other Names:

  • Des(1-3)igf-I
  • Des-(1-3)-igf-1
  • Igf-1
  • Insulin-like growth factor 1
  • Somatomedin C
IGF-1 DES Peptide chemical structure Made in USA

Mechanism of Action:

IGF-1 DES works by stimulating growth and repair in the body. It also aids in producing new cells, which makes it a popular choice for patients undergoing chemotherapy or radiation therapy. The drug has been found to aid in treating several illnesses by promoting cell growth and improving glucose metabolism. IGF-1 DES is a growth factor used in human medicine. It is also an important hormone that helps in the growth of muscle and bone mass. IGF-1 DES has been used in clinical studies to treat a variety of medical conditions.

Clinical applications of IGF-1 DES:

IGF-1 DES is a growth factor that has been proven to have beneficial effects on the human body. The following are some of the clinical applications of IGF-1 DES:

  • Autism:

IGF-1 has been linked to a variety of neurological disorders, including autism, according to research. Children with autism had lower IGF-1 levels than age-matched controls, implying that low IGF-1 levels in the brain, especially at a young age, may impair normal development and play a role in the pathogenesis of autism. IGF-II and analogs such as IGF-1 DES have been shown to restore all impairments associated with autism in mice models.

  • Neurological diseases:

IGF-1 has long been known to affect neuron development, differentiation, and survival significantly. The protein is a key player in synapse development. Therefore, it’s important for learning, memory, and other processes. IGF-1 plays a crucial role in the formation and maintenance of mature synapses. According to research, IGF-1 is required to maintain correct presynaptic synapsin-1, a protein that controls neurotransmitter release.

  • Cognitive benefits:

IGF-1 is important in adults as well as children. In adults, the peptide is heavily modified in the brain to make it shorter, indicating that analogs like IGF-1 DES may have better therapeutic potential than intact IGF-1. Molecules like IGF-1 DES also penetrate the blood-brain barrier more readily, making them more effective when administered exogenously. In adults, IGF-1 and its analogs have been shown to reduce neuronal death and protect neurons against insults like stroke, Alzheimer’s disease, Parkinson’s disease.

Other clinical applications include:

  • Anti-aging effects, rejuvenation & the ability to slow down the aging
  • Ability to induce muscle hyperplasia – the growth of new muscle cells


The information provided aboutIGF-1 DES in this section is only for research and disbursement of knowledge. The material collected in this article is meant for informational purposes about IGF 1 and is not to be considered instructional in any way. Moreover, we have further empathized with this by making sure no dosage information of IGF-1 DES or recommendations about its consumption are mentioned. The information available in this article is a collection from different recognized studies and researches conducted by known experts and researchers in controlled medical facilities and institutions. Furthermore, the information provided in the article is not to encourage the reader to start its consumption or as an advertisement of the product.  Administering any supplement or medication not FDA approved may be harmful and cause serious illness. Peptide Pros insists that none of their products be ingested under any circumstances.


  • Ballard, F. J., Wallace, J. C., Francis, G. L., Read, L. C., & Tomas, F. M. (1996). Des (1–3) IGF-I: a truncated form of insulin-like growth factor-I. The international journal of biochemistry & cell biology28(10), 1085-1087.
  • Ballard, F. J., Walton, P. E., Bastian, S., Tomas, F. M., Wallace, J. C., & Francis, G. L. (1993). Effects of interactions between IGFBPs and IGFs on the plasma clearance and in vivo biological activities of IGFs and IGF analogs. Growth Regulation, 3(1), 40-44.
  • Canitano, R. (2014). New experimental treatments for core social domain in autism spectrum disorders. Frontiers in pediatrics2, 61.
  • Steinmetz, A. B., Stern, S. A., Kohtz, A. S., Descalzi, G., & Alberini, C. M. (2018). Insulin-like growth factor II targets the mTOR pathway to reverse autism-like phenotypes in mice. Journal of Neuroscience, 38(4), 1015-1029.
  • Górecki, D. C., Beręsewicz, M., & Zabłocka, B. (2007). Neuroprotective effects of short peptides derived from the Insulin-like growth factor 1. Neurochemistry international51(8), 451-458.

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