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Aromasin-Exemestane-25mg-30ML

What is Exemestane? Research Information

Product information:

  • Molecular formula – C20H24O2
  • Molecular weight – 296.4
  • Storage temperature – 2 to 8 Celcius

Other names:

  • 6-methylideneandrosta-1,4-diene-3,17-dione
  • 107868-30-4
  • Aromasine
  • EXEMESTANE
  • Aromasin
  • PNU-155971
  • NY22HMQ4BX
Exemestane Molecule Structure

Discovery:

Exemestane Aromasin is an example of the drug relating to an irreversible aromatase inhibitor, discovered and approved in 1987. Initially, this enzyme/drug was introduced to treat patients with breast cancer resistant to the other antiestrogenic therapy. Now, Exemestane has potential advantages for other uses because of its potency and route of oral administrations.

Mechanism of action:

  • Breast cancer cells growth can be estrogen hormone-dependent. Exemestane (Aromasin) is the chief enzyme that helps in converting androgens to estrogens in pre and post-menopausal females.

In pre-menopausal women, the ovary is the main source of estrogen or estradiol. However, in post-menopausal women, the principal source of estrogen (circulating) is through the ovarian and adrenal androgens conversion to estrogen via this enzyme. Aromatase inhibition can be a selective and effective treatment for estrogen deprivation in postmenopausal patients with hormone-dependent breast cancer. Exemestane is the:

  • Steroidal aromatase inactivator
  • Related (structurally) to natural substrate androstenedione
  • Irreversible

Exemestane irreversibly binds to the sites (active) to cause permanent inhibition for restoring the enzymatic function.

Clinical applications

Treatment of breast cancer:

Several endocrine strategies are available for hormone-sensitive breast cancers. Exemestane is a third-generation AI (aromatase inhibitor) steroidal drug that is beneficial for the treatment of breast cancer. In metastatic diseases, Exemestane can play its role as the first and second-line treatment for postmenopausal women with advanced estrogen-receptor-positive cancer. Exemestane also has its approval for the adjuvant postmenopausal treatment.

Anti-proliferative effects in lungs cancer:

Aromatase enzyme complex catalyzes the final step of estrogen synthesis, which is present in several other tissues. Exemestane helps decrease the proliferation of the cancer cells and increases apoptosis in all the cell lines. In lungs tumour, AI’s can effectively reduce the estrogen biosynthesis to inhibit the estrogen-dependent pathways.

Anti-inflammatory properties:

Exemestane is the potent enzyme against hypoxia, damage from UV radiations, oxidation activity, and other anti-inflammatory properties. All of these actions are somewhat similar to the action of sulforaphane. After the single exemestane 25 mg dosage, the maximum suppression of the levels of circulating estrogens occurs at 2-3 days after the treatment.

Exemestane is the antineoplastic drug that treats breast cancer among women (postmenopausal). Most of the time, exemestane therapy is given to women or patients who have cancer progression even after administering tamoxifen (Soltamox, Nolvadex) for 2-3 years.

According to the ASCO (American Society of Clinical Oncology) guidelines, Exemestane is the best alternative for raloxifene and tamoxifen to prevent invasive breast cancer among women at higher risks.

Disclaimer:

The information provided about Exemestane in this section is only for the purpose of research advancement and disbursement of knowledge. It is particularly meant for researchers and experts who plan to either Exemestane for investigative purposes or would like to increase their knowledge. The material collected in this article is meant for informational purposes and is not to be considered instructional in any way. Moreover, we have further empathized with this by making sure no dosage information of Exemestane or recommendations about its way of consumption are mentioned. The information available in this article is a collection from different recognized studies and researches conducted by known experts and researchers in controlled medical facilities and institutions. Furthermore, the information provided in the article is not to encourage the reader to start its consumption or as an advertisement of the product. Administering any supplement or medication not FDA approved may be harmful and may cause serious illness.  Peptide Pros insist that none of their products be ingested under any circumstances.

References:

  • Ethinylestradiol| NY22HMQ4BX | Pubchem. (n.d.). Pubchem| https://pubchem.ncbi.nlm.nih.gov/compound/Ethinylestradiol
  • Exemestane| Medscape. (n.d.). drug/aromasin-exemestane | https://reference.medscape.com/drug/aromasin-exemestane-342216
  • Exemestane| Sciencedirect. (n.d.). chemistry/exemestane | https://www.sciencedirect.com/topics/chemistry/exemestane
  • Zucchini, G., Geuna, E., Milani, A., Aversa, C., Martinello, R., & Montemurro, F. (2015). Clinical utility of exemestane in the treatment of breast cancer. International journal of women’s health7, 551.
  • Villarreal-Garza, C., Ferrigno, A. S., De la Garza-Ramos, C., Barragan-Carrillo, R., Lambertini, M., & Azim, H. A. (2020). Clinical utility of genomic signatures in young breast cancer patients: a systematic review. NPJ breast cancer6(1), 1-9.
  • He, D. X., & Ma, X. (2016). Clinical utility of letrozole in the treatment of breast cancer: a Chinese perspective. OncoTargets and therapy9, 1077.
  • Sobral, A. F., Amaral, C., Correia-da-Silva, G., & Teixeira, N. (2016). Unravelling exemestane: From biology to clinical prospects. The Journal of steroid biochemistry and molecular biology163, 1-11.
  • Koutras, A., Giannopoulou, E., Kritikou, I., Antonacopoulou, A., Evans, T. J., Papavassiliou, A. G., & Kalofonos, H. (2009). Antiproliferative effect of exemestane in lung cancer cells. Molecular Cancer8(1), 1-12.

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