Received over 11,000 five star verified reviews, and counting
DSIP 5mg

What is DSIP (Delta-Sleep-Inducing Peptide) ? Research Information

Product information:

  • Empirical formula – C35H48N10O15
  • Molecular weight – 848.81
  • Amino acid sequence – Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu-OH
  • Appearance – white powdery substance
DSIP Peptide chemical structure Made in USA

Other names:

  • Emideltide
  • Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
  • Sleep inducing peptide
  • DSIP
  • Human Delta-Sleep Inducing Peptide
  • Glucocorticoid-Induced Leucine Zipper
  • GILZ
  • TSC22 Domain Family Protein 3
  • TSC-22R
  • TSC22D3


The delta-sleep-inducing peptide had its first discovery by a Swiss group, Schoenenberger-Monnier, in 1974. This group isolated the first compound of DSIP from the cerebral venous blood present in the rabbits in a sleepy state (induced sleep).  These rabbits had deep electrical stimulation in their intralaminar thalamic area of the brain.

After its first discovery, scientists found DSIP peptide in other subjects as the human hypothalamus, pituitary gland, limbic system, body fluids, tissues, body, and peripheral organs.

Moreover, DSIP is also abundantly present in the gut and pancreas secretory cells, where it works with the glucagon hormone.

Mechanism of action:

DSIP is a naturally occurring peptide and neuromodulator which is studied for it’s sleep-promoting and physiological functions in the body. Typically, DSIP occurs naturally in the brain and can easily cross the BBB (blood-brain barrier).

When it crosses the BBB, it can directly have a positive effect on the brain and whole body to:

  • Cope with stress-related problems and symptoms
  • Deal with the painful body conditions
  • Treat problems with poor sleep and insomnia

DSIP can target several brain areas to promote sleep. This peptide doesn’t get denatured by the effects of enzymes and is easily absorbed in the human gut. DSIP has a positive effect in regulating the circadian rhythm of humans. Patients suffering from depression and schizophrenia show low concentrations of this peptide in their bodies.

What is DSIP
Delta sleep-inducing peptide (DSIP) Standard Curve.

Clinical application:

  • Sleep and DSIP Peptide:

Since the discovery of this peptide, scientists have been working on its effects for human benefits. According to a research study, DSIP is a beneficial agent for sleep-related problems. DSIP is a sleep-promoting agent other than the sedative. It doesn’t only induce sleep like sedative medicines, but DSIP modifies the problematic area of the brain to regulate the sleeping cycle.

This synthetic substance and its consumption doesn’t cause drug tolerance or resistance.

  • Convulsive activity and DSIP:

A research study states that DSIP peptide can control or suppress the convulsive activity in the cerebral cortex and foci after administration. DSIP can prevent convulsion development and influence substantia nigra (reticular portion) to work as an anti-convulsive agent.

  • DSIP and hormones:

In the pituitary gland, DSIP co-exists with the other non-peptide and peptide mediators as ACTH (adrenocorticotrophic hormone), CLIP (corticotropin-like intermediate peptide), TSH (thyroid-stimulating hormone), MCH (melanin-concentrating hormone), and MSH (melanocyte-stimulating hormone). DSIP administration can improve the regulation and production of human endocrine glands. A unique effect of this peptide is that it can increase the quantity of desired hormones and vice versa.


The information provided about DSIP Peptide in this section is only for the purpose of research advancement and disbursement of knowledge. The material collected in this article is meant for informational purposes about DSIP Peptide and is not to be considered instructional in any way. Moreover, we have further empathized with this by making sure no dosage information of DSIP or recommendations about its way of consumption are mentioned. The information available in this article is a collection from different recognized studies and researches conducted by known experts and researchers in controlled medical facilities and institutions. Furthermore, the information provided in the article is not to encourage the reader to start its consumption or as an advertisement of the product. Administering any supplement or medication not FDA approved may be harmful and may cause serious illness. Peptide Pros insist that none of their products be ingested under any circumstances.


  • Pollard, B. J., & Pomfrett, C. J. D. (2001). Delta sleep-inducing peptide. European journal of anaesthesiology18(7), 419-422.
  • Graf, M. V., & Kastin, A. J. (1986). Delta-sleep-inducing peptide (DSIP): an update. Peptides7(6), 1165-1187.
  • Shandra, A. A., Godlevskii, L. S., Mazarati, A. M., Oleshko, A. A., & Mikhaleva, I. I. (1993). The influence of the delta-sleep-inducing peptide on convulsive activity. Neuroscience and behavioral physiology23(5), 480-485.
  • Kovalzon, V. M., & Strekalova, T. V. (2006). Delta sleep‐inducing peptide (DSIP): a still unresolved riddle. Journal of neurochemistry97(2), 303-309.
  • Vallet, P. G., Charnay, Y., & Bouras, C. (1990). Distribution and colocalization of delta sleep-inducing peptide and luteinizing hormone-releasing hormone in the aged human brain: an immunohistochemical study. Journal of chemical neuroanatomy3(3), 207-214.

Where to buy DSIP Peptide?

If you’re looking to buy DSIP for research purposes, shop at Peptide Pros, the most reliable supplier of the highest quality USA peptides for sale online: