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What is Avanafil? Research Information

Peptides

Product information:

  • Chemical formula – C23H26ClN7O3
  • Molecular weight – 483.9 g/mol
  • Routes of administration – oral

Other names:

  • Avanafil
  • 330784-47-9
  • TA-1790
  • STENDRA
  • UNII-DR5S136IVO
  •  DR5S136IVO
  • CHEBI:66876

Discovery of Avanafil:

Avanafil was discovered and approved in the year 2012 by the FDA for the treatment of erectile dysfunction. Furthermore, it got approval from the EMA in the year 2013. Avanafil was invented at the Tanabe Seiyaku Co, which is now known as Mitsubishi Tanabe Pharma. In the United States, Avanafil had exclusive rights for distribution by Metuchen Pharmaceuticals.

Mechanism of action:

Avanafil is a drug (PDEF5 inhibitor) that was approved for the treatment of erectile dysfunction by the EMA and FDA. Avanafil helps in the selective inhibition of PDE5 to inhibit the degradation of cGMP (cyclic guanosine monophosphate), which is found in the corpus cavernosum smooth muscles in the penis. The physiological mechanism behind this action is the release of NO (nitric oxide) in the corpus cavernosum during the time of sexual stimulation. Nitric oxide activates the guanylate cyclase enzyme, which increases the cGMP’s levels. As a result of this, smooth muscles relax in the corpus cavernosum by allowing the inflow of blood into the penis. In comparison to other PDE5 inhibitors, Avanafil has faster action onset.

Clinical applications:

Avanafil for erectile dysfunction:

Avanafil has indications for treating men with sexual impotence or erectile dysfunction. Avanafil belongs to the specific group of medicines known as PDE5 (phosphodiesterase) inhibitors. These medications help in preventing the too-immediate working of the type-5 phosphodiesterase enzyme in the penis.

Erectile dysfunction is the condition in which the penis doesn’t harden or expand during the time of sexual excitation. In a time of sexual stimulation, the body’s normal response is to increase the flow of blood to the penis to produce an erection. The control of this enzyme helps in maintaining the erection faster when increased blood flow strokes the penis. Without any physical activity in the penis, Avanafil may work less efficiently to cause the erection of the penis.

Most of the time, erectile dysfunction is either due to comorbidity (cardiovascular disease) or physical trauma to the genitals. In such cases, Avanafil might not work as a primary treatment for erectile dysfunction. The physiological causes of erectile dysfunction are primarily treated by Avanafil administration.

Disclaimer

The information provided about Avanafil in this section is only for research advancement and disbursement of knowledge. The material collected in this article is meant for informational purposes about Avanafil. It is not to be considered instructional in any way. Moreover, we have further empathized with this by making sure no dosage information of Avanafil or recommendations about its way of consumption is mentioned. The information available in this article is a collection from different recognized studies and researches conducted by known experts and researchers in controlled medical facilities and institutions. Furthermore, the information provided in the article is not to encourage the reader to start its consumption or as an advertisement of the product. Administering any supplement or medication not FDA approved may be harmful and may cause serious illness.  Peptide Pros insist that none of their products be ingested under any circumstances.

References:

  • Avanafil |Pubchem| Link: https://pubchem.ncbi.nlm.nih.gov/compound/Avanafil
  • Avanafil |ChemSpider| Link: http://www.chemspider.com/Chemical-Structure.8045620.html
  • Kyle, J. A., Brown, D. A., & Hill, J. K. (2013). Avanafil for erectile dysfunction. Annals of Pharmacotherapy, 47(10), 1312-1320.
  • Alwaal, A., Al-Mannie, R., & Carrier, S. (2011). Prospects in the treatment of erectile dysfunction: focus on avanafil. Drug design, development and therapy, 5, 435.
  • Sanford, M. (2013). Avanafil: a review of its use in patients with erectile dysfunction. Drugs & ageing, 30(10), 853-862.
  • Kedia, G. T., Ückert, S., Assadi-Pour, F., Kuczyk, M. A., & Albrecht, K. (2013). Avanafil for the treatment of erectile dysfunction: initial data and clinical key properties. Therapeutic advances in urology, 5(1), 35-41.
  • Zhao, C., Kim, S. W., Yang, D. Y., Kim, J. J., Park, N. C., Lee, S. W., … & Park, J. K. (2012). Efficacy and safety of avanafil for treating erectile dysfunction: results of a multicenter, randomized, double-blind, placebo-controlled trial. BJU international, 110(11), 1801-1806.

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Rob Alotta