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What is Anastrozole? Research Information

Product information:

Chemical formula – C17H19N5

Molecular weight – 293.4

Other names:

  • anastrozole
  • 2,2′-(5-((1H-1,2,4-triazol-1-yl)methyl)-1,3-phenylene)bis(2-methylpropanenitrile)
  • 120511-73-1
  • Arimidex
  • ZD-1033
  • UNII-2Z07MYW1AZ
  • 2-[3-(2-cyanopropan-2-yl)-5-(1,2,4-triazol-1-ylmethyl)phenyl]-2-methylpropanenitrile
  • alpha,alpha,alpha’,alpha’-Tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-m-benzenediacetonitrile
  • ICI-D1033
  • 2Z07MYW1AZ
  • ZD1033
  • ICI D1033

Discovery of anastrozole:

Anastrozole is the AI (aromatase inhibitor) non-steroidal drug used to reduce estrogen concentration in postmenopausal women with positive breast cancer (estrogen-positive type). The first patent for Anastrozole was developed in the year 1987. However, the approval to use Anastrozole was given in the year 1995. Anastrozole is a generic medicine or drug. According to a statistical survey in 2019, Anastrozole was the 176th most frequently prescribed medicine by doctors for patients with different problems in the United States.

Mechanism of action:

Anastrozole tends to exert an anti-estrogenic effect through the competitive and selective inhibition of the enzymes (aromatase) found predominantly in the fatty tissues, liver, and adrenal glands. Most breast cancers are hormone receptor-positive, which means that their growth has maintenance or stimulation through the presence of different hormones such as progesterone and estrogen. Among postmenopausal women, the primary derivative of estrogen is through the conversion of androgens (adrenally produced) into estrogen through the aromatase enzyme. Anastrozole can effectively suppress circulating estrogen levels and gradually suppress the growth of different hormone-positive tumors in the body by inhibiting estrogen biosynthesis.

Clinical applications:

Breast cancer:

According to a clinical trial conducted on women with a high risk of cancer, Anastrozole can help postmenopausal women with estrogen-positive breast cancer for years, even if they have discontinued their therapy. According to different researches, post-menopausal women have higher risks of breast cancer, which is significantly reduced with the therapy of anastrozole drug. These effects are more significant in the patients with the estrogen-positive cancer type in comparison to estrogen-negative breast cancer.

Along with other treatments, Anastrozole is used to treat the early symptoms of breast cancer among women who are currently suffering from menopause. Anastrozole serves as the first choice of treatment to control the spread of cancer to the other parts or tissues of the body. Most of the time, Anastrozole is given to the patients who have shown resistance to the treatment with tamoxifen.

Anastrozole and men:

Men and women both have different concentrations of estrogen in their bodies. A healthy estrogen hormone level among men helps maintain bone health, glucose metabolism, reproductive functioning, and vasomotor stability. According to recent research, a balanced ratio of estrogen and testosterone in men is vital for the body’s normal functioning. In case of increased abnormal estrogen concentration, Anastrozole could be the best solution for estrogen inhibition to gain maximum benefits for health.

Disclaimer

The information provided about Anastrozole in this section is only for research advancement and disbursement of knowledge. The material collected in this article is meant for informational purposes about Anastrozole. It is not to be considered instructional in any way. Moreover, we have further empathized with this by making sure no dosage information of Anastrozole or recommendations about its way of consumption is mentioned. The information available in this article is a collection from different recognized studies and researches conducted by known experts and researchers in controlled medical facilities and institutions. Furthermore, the information provided in the article is not to encourage the reader to start its consumption or as an advertisement of the product. Administering any supplement or medication not FDA approved may be harmful and may cause serious illness.  Peptide Pros insist that none of their products be ingested under any circumstances.

References:

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