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What is AICAR? Research Information

Product information:

  • Chemical formula – C9H15N4O8P
  • Weight – average weight (338.2), Monoisotopic weight (338.06)
  • Molecular weight – 64615.2 Da
  • Molecular framework – heteromonocyclic aromatic compounds

Other names:

  • Aminoimidazole-4-carboxamide ribonucleotide
  • AICA ribonucleotide
  • 5-Amino-1-β-D-ribofuranosyl-imidazole-4-carboxamide
  • AICA-ribonucleotide
  • ZMP
  • 5′-phospho-ribosyl-5-amino-4-imidazole carboxamide
  • 5-amino-1-(5-phospho-D-ribosyl)-imidazole-4-carboxamide
AICAR Peptide chemical structure Made in USA


AICAR is an intermediate belonging to the inosine monophosphate generation. AICAR is an AMP (adenosine monophosphate) analog that can effectively stimulate the AMPK (AMP-dependent protein kinase) activity. For the first time, AICAR was used in the year 1980 as a drug to prevent the blood flow to the cardiac region during the surgery process.

Currently, this drug has uses in the treatment of diabetes and modification of muscles or tissues of the body. Moreover, AMPK activation can also regulate muscle physiology, muscle endurance, and spatial memory function.

Mechanism of action:

AICAR (an adenosine analog) enters the cardiac cells to inhibit adenosine deaminase and adenosine kinase. This entry enhances the nucleotide re-synthesis rate leading to an increase in adenosine generation from APM (adenosine monophosphate) during myocardial ischemia condition.

In a condition of cardiac myocytes, to activate AMPK, acadesine phosphorylates to AICAR without even changing the nucleotides levels. Moreover, AICAR is also capable of entering the de novo synthesis path way for adenosine synthesis and inhibiting adenosine deaminase concentration. This cascade leads to an increase in ATP concentration and levels of adenosine also proliferate.

Proposed applications:

Motor coordination and cognition:

Normal aging is the result of a decline in muscle and memory function. In the animal study, researchers showed the benefits of AICAR for improved motor coordination and cognition. AICAR was effective in gene expression, enriched plasticity, and enhanced neuronal development. Endurance-related factors of AICAR can also mediate both brain health and muscle condition with aging. This shows a new therapeutic role of AICAR in health.

Exercise mimetic activity of AICAR:

According to a research study, researchers experimented with physical running and use of AICA (5-Aminoimidazole-4-carboxamide 1-β-D-ribofuranoside). These experiments were conducted for about 7 days and the results were recorded on 1, 3, and 7th days.

According to the results of the study, both of these regimens were equally effective in increasing BDNF (brain-derived neurotrophic factor) protein levels and DG (dentate gyrus) cells. There was an exceptional overlap between the activity of AICA and running for the regulation of metabolism, neuronal, and mitochondrial related genes.


The information provided about AICAR in this section is only for the purpose of research advancement and disbursement of knowledge. The material collected in this article is meant for informational purposes about AICAR Peptide and is not to be considered instructional in any way. Moreover, we have further empathized with this by making sure no dosage information of AICAR Peptide or recommendations about its way of consumption are mentioned. The information available in this article is a collection from different recognized studies and researches conducted by known experts and researchers in controlled medical facilities and institutions. Furthermore, the information provided in the article is not to encourage the reader to start its consumption or as an advertisement of the product. Administering any supplement or medication not FDA approved may be harmful and may cause serious illness.  Peptide Pros insist that none of their products be ingested under any circumstances.


  1. Guerrieri, D., & van Praag, H. (2015). Exercise-mimetic AICAR transiently benefits brain function. Oncotarget6(21), 18293.
  2. Kobilo, T., Guerrieri, D., Zhang, Y., Collica, S. C., Becker, K. G., & van Praag, H. (2014). AMPK agonist AICAR improves cognition and motor coordination in young and aged mice. Learning & memory21(2), 119-126.
  3. Ruegsegger, G. N., & Booth, F. W. (2018). Health benefits of exercise. Cold Spring Harbor perspectives in medicine8(7), a029694.
  4. Shi, X., Ai, Z., Du, J., Cao, L., Guo, Z., & Zhang, Y. (2014). MicroRNA modulation induced by AICA ribonucleotide in J1 mouse ES cells. PloS one9(7), e103724.
  5. Mendelsohn, L. G., Shih, C., Schultz, R. M., & Worzalla, J. F. (1996). Biochemistry and pharmacology of glycinamide ribonucleotide formyltransferase inhibitors: LY309887 and lometrexol. Investigational new drugs14(3), 287-294.

Where to buy AICA Ribonucleotide?

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